GI-MAP^™ – DNA Stool Analysis by qPCR

In the last few decades, DNA analysis has transformed the field of microbiology. Almost all research of microbes utilizes DNA methodology. The National Institute of Health (NIH) has followed suit with initiatives including the Human Microbiome Project, which characterized the microbiome of 15 habitats of the body using DNA analysis. The GI-MAP comprehensive stool test was developed to provide practitioners a diagnostic tool that offers unmatched insight into a patient’s unique microbiome. The GI-MAP stool analysis evaluates the DNA of the organisms living within the gut using the most advanced qPCR technology for results you can rely on.

Five new bacterial biomarkers. The additions include keystone species and important groups that may impact health in a variety of ways, including: production of short-chain fatty acids, mucus metabolism, methane production, and promotion of anti-inflammatory regulatory T cells, and production of inflammatory LPS.

These markers will further enhance insights into gastrointestinal and immune health provided by GI-MAP DNA Stool Analysis.

New Commensal Markers

• Akkermansia muciniphila – Plays a significant role in the gut ecosystem by breaking down mucus polysaccharides. Low levels are associated with obesity and metabolic dysfunction, while high levels are linked to multiple sclerosis.
• Clostridia (class) – Important producers of short-chain fatty acids, and have many well-documented roles in promoting a healthy intestinal barrier, immune balance, and protection against pathogens.
• Faecalibacterium prausnitzii – Well-known keystone species and a major butyrate producer. Many chronic inflammatory and autoimmune diseases have been associated with low levels of F. prausnitzii.

New Opportunistic Bacteria

• Methanobacteriaceae (family) – Family of bacteria-like microbes that produce methane. High levels have been linked to chronic constipation, as well as some types of SIBO and IBS.
• Fusobacterium spp. – Commonly found in the oral cavity, and may also be found in the intestine. Some are considered opportunistic pathogens, and may promote inflammatory processes and or advanced disease states.

More than ever before, we are keenly aware of the health benefits or disease risks brought about by the microorganisms that inhabit the human body. Culture techniques, previously the standard, left up to 50% of bacterial species virtually invisible. Because most of the bacteria of the GI tract are anaerobes, culture based methods cannot cultivate them which leaves a large blind spot for clinicians when trying to diagnose the source of infection.

These labs are for nutrition analysis only. They are not intended to diagnose, treat, cure, or prevent disease. They are not intended to replace the advice of a physician. Always consult your physician on any matters regarding your health and before nutritional changes.

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